Are casual or non-fans welcome? If your aim is to party down with only the die-hards, (politely) make that clear in the invitation so less-fanatical friends can make alternate plans.
Make room on the sidelines
If your gathering is going to be split between die-hard football fans and folks who are just in it for the dip and halftime nip slips, consider drawing some clear lines on the field of play. This might mean you'll have to clean up your bedroom or den, but that's a small price to pay for peace.
Draft backup hosts
ou might be the best host in the history of the game, and have all your bases covered (apologies for the mixed sports metaphor), but accept offers of help if you can. The guest might simply be at a loss for something to do. Consider tasking them with beer runs, cheese grating or dish duty and consider it a victory for your mad hospitality skills.