Dempsey will be briefed on the ongoing military transition, where Afghan security forces are taking greater control of their country.
He will meet with Marine Corps Gen. Joseph F. Dunford, who took command of ISAF about two months ago.
"One of the things I'm going to ask (Dunford) is ... what have you learned," Dempsey told the American Forces Press Service.
"If he tells me 'Nothing,' I'm going to say, 'Maybe we got the wrong guy.'"
Dempsey spokesman Col. David Lapan later told CNN that the chairman was simply joking when he made the remark about Dunford. Dempsey has total confidence in Dunford, Lapan said.