"The evidence in the case against Lance Armstrong is beyond strong; it is as strong as, or stronger than, that presented in any case brought by USADA over the initial twelve years of USADA's existence," said the organization, which is not a governmental agency but is designated by Congress as the country's official anti-doping organization for Olympic sports.
Armstrong himself hasn't commented directly on the case. He posted to Twitter Wednesday night, however, saying he was "hanging with my family, unaffected" and thinking about an upcoming event for his charity.
His lawyer, Tim Herman, called the agency's report a "one-sided hatchet job" and a "government-funded witch hunt."
A spokesman for the U.S. Attorney's office in Los Angeles, which ran the investigation that was closed in February, declined to comment on whether the evidence released publicly Wednesday would spur renewed interest in possible criminal sanctions against Armstrong or anyone else associated with the team.
Bruce Deming, a former federal prosecutor and avid amateur cyclist himself, said he doubted the criminal case would be reopened.
"The feds knew what USADA knew. USADA knew what the feds knew. So this is not new information to the prosecutors, I don't think," he said.
In fact, he said, he suspects the information revealed Wednesday is largely similar to what federal prosecutors unveiled.
"This investigation against Lance, which you know involved multiple federal agencies and a very large, well-organized federal investigation and what has to be millions of dollars spent, came up with apparently not enough hard evidence to charge Lance Armstrong with a parking ticket," Deming said.
Still, the report has had an impact on some fans, for whom the evidence appeared to sour their opinion of Armstrong.
"I am sad and have finally accepted there really are no true heroes in our world," one Facebook fan wrote.
"On behalf of pretty much everyone who has held you in high regard... Looked on as an idol in the wake of your excellence in your sport... Bought your books and aspired to be as (successful) as you are... If the allegations are true then you have duped your country and fellow athletes," wrote another.
Still, Howard Bragman, an expert in crisis communications, said he does not expect the accusations will have any significant impact on Armstrong's legacy.
"He's done amazing things for people with cancer," Bragman said. "He's given a lot of people hope in this world. And to many millions of Americans and people around the world, Lance Armstrong will always be a hero. And none of these allegations are ever going to change that."