'Path to justice'
U.S. President Barack Obama, who visited with Mandela's family in South Africa last month, also sent birthday wishes.
"People everywhere have the opportunity to honor Madiba through individual and collective acts of service," he said in a prepared statement. "Through our own lives, by heeding his example, we can honor the man who showed his own people -- and the world -- the path to justice, equality and freedom."
The frail icon has not appeared in public for years, but he retains his popularity as the father of democracy and emblem of the nation's fight against apartheid.
His defiance of white minority rule focused the world's attention on apartheid, the legalized racial segregation enforced by the South African government until 1994.
His hospitalization has given his birthday a sentimental touch. The South African Embassy in the United States said it will be the biggest celebration since his birthday in 1990, the year he was freed from prison.
The festivities are not limited to South Africa. In the United States, the embassy said 18 cities, including the nation's capital, will hold various events to celebrate his birthday.
Mandela's family has faced an anxious few weeks while the former president has been hospitalized.
His daughter, Zindzi Mandela-Motlhajwa, told the South African Press Association on Thursday that her father was making "remarkable progress" and that she looks forward to seeing him back home soon.
A public family feud over where three of Mandela's deceased children should be buried has added to their stress.
Last month, family members sued Mandela's grandson to return the remains to Qunu, the former president's childhood home.
The grandson, Mandla Mandela, exhumed the remains from Qunu two years ago, then reburied them in Mvezo, where he's built a visitor center. They were returned to Qunu this month after a court order.
The matter is back in court Thursday, said Freddie Pilusa, a spokesman for the grandson.
"Mandla does not want the graves repatriated, but he wants the decision forcing him to move them rescinded because it was based on incorrect information," he said.
Mandela, a Nobel peace laureate, spent 27 years in prison for fighting against oppression of minorities in South Africa. He became the nation's first black president in 1994, four years after he was freed from prison.