Cleveland Fed President Sandra Pianalto, who was slated to be a voting member on the Fed's policymaking committee next year, is also stepping down.
Vice-chair Janet Yellen is a wild card. Obama has said he's considering her for Bernanke's top job, but other candidates, like his former adviser Larry Summers, are also in the running. If Yellen doesn't get the job, will she stay or will she go?
All of this personnel turnover adds some uncertainty about future Fed policy, and doesn't come at the most convenient time.
If one thing's for sure, it's that the Fed is in uncharted territory on the PR front. Its 100th anniversary year is not turning out to be a quiet one.
"The communications policy is new and they're still getting the kinks out," Collins said.