DAVIE, Fla. -

Florida's two U.S. Senate candidates will square off in their only face-to-face debate Wednesday at Nova Southeastern University in Davie.

The debate between Democratic incumbent U.S. Sen. Bill Nelson and the challenger, Republican U.S. Rep. Connie Mack IV, is sponsored by Leadership Florida and the Florida Press Association.

"This Senate debate will focus on state issues, and how these gentlemen see they’re going to represent Florida in Congress," said Susan MacManus, professor of political science at the University of South Florida. "But still, after the acrimonious tone of the presidential debate, the last thing undecideds on this race want to hear is more of that."

The debate comes as thousands of people have already cast their votes with absentee ballots.

The race could have implications on balance of power in the Senate. Republicans need to gain four seats to have a majority. Outside groups supporting both sides have spent millions of dollars trying to influence the Florida race.

Nelson is seeking his third term.

Channel 4's Kent Justice is in Davie and will provide full coverage on The Local Station at 10 and 11 p.m.