Kaepernick, a second-round draft pick out of Nevada last year, made his first career NFL start. Campbell, in his eighth NFL season, started for the 76th time in his career, but the first time for the Bears.
Campbell entered the game with 14,511 career passing yards to just 241 for Kaepernick. However, once the game began, it was Kaepernick who played like a veteran, helping the 49ers beat the Bears at Candlestick for the eighth straight time.
Kaepernick completed 16 of 23 passes for 243 yards and two touchdowns with no interceptions and a 133.1 passer rating. He was sacked only once.
Campbell went 14 of 22 for 107 yards with one touchdown, two interceptions and a 52.7 passer rating. Campbell was sacked five times, 4 1/2 of those by outside linebacker Aldon Smith. Aldon Smith abused Bears tackles J'Marcus Webb and Gabe Carimi as he took over the NFL sack lead with 14.
San Francisco tight end Vernon Davis had a big night, catching six passes for 83 yards and a touchdown.
The 49ers improved to 7-2-1 and increased their lead over 6-4 Seattle in the NFC West. Chicago fell to 7-3 and into a first-place tie with Green Bay in the NFC North.
Monday night's game featured the NFL's two stingiest defenses based on points allowed. The 49ers were ranked No. 1, allowing just 14.1 points per game, and the Bears were No. 2 at 14.8.
Kaepernick and the 49ers had 20 points by halftime, while the Bears were scoreless.
The 49ers extended their lead to 27-0 with 11:05 left in the third on Kaepernick's 10-yard touchdown pass to Michael Crabtree.
The Bears finally scored with 3:43 left in the third on Campbell's 13-yard touchdown pass to Brandon Marshall, cutting San Francisco's lead to 27-7. But late in the third quarter, Campbell overthrew Earl Bennett, and 49ers safety Dashon Goldson intercepted at the Chicago 37-yard line. David Akers' 32-yard field goal made it 30-7 with 11:46 remaining.
The 49ers increased their lead to 32-7 with a safety with 9:32 remaining.
San Francisco rolled up 249 yards of total offense in the first half to just 35 for the Bears.
Kaepernick was 12-for-15 for 184 yards and a touchdown before halftime. Campbell was 4-for-8 for 21 yards and one interception in the first half, and he was sacked three times -- each by outside linebacker Aldon Smith.
Kaepernick completed seven of his first eight throws for 114 yards and his first NFL touchdown pass, leading the 49ers to a 10-0 lead. At that point, he had a perfect passer rating of 158.3. So much for nerves.
The 49ers took the opening kickoff and marched 68 yards in nine plays for David Akers' 32-yard field goal, grabbing a 3-0 lead. Kaepernick was 4-for-5 for 45 yards on the drive, connecting with tight end Vernon Davis twice for a total of 34 yards.
The Bears went three-and-out as Aldon Smith sacked Campbell on third-and-2 from the 28, forcing a punt. Kaepernick went back to work. On third-and-7 from his 40, Kaepernick lofted a 57-yard pass down the right sideline that hit wide receiver Kyle Williams in stride.
Williams beat nickel cornerback Kelvin Hayden on the play, and Chris Conte made a touchdown-saving tackle at the 3. On first-and-goal, Kaepernick connected with Davis -- wide open in the right corner of the end zone -- for a 3-yard touchdown pass with 6:14 left in the first quarter.
The 49ers forced another Chicago punt late in the first quarter and drove 96 yards in eight plays for another touchdown. Kendall Hunter scored on a 14-yard burst up the middle, increasing the 49ers' lead to 17-0 with 12:40 left in the half.