Patrick Ebert and Oscar Gonzalez scored in the first 12 minutes for Valladolid, but Manucho put through his own net soon after halftime before teammate Gary Medel was sent off for a second booking on 63.
In England, Newcastle moved up to 14th place in the Premier League with a 3-0 win over struggling Wigan, who had defender Maynor Figueroa sent off after only 12 minutes.
Figueroa was red-carded alter fouling Papiss Cisse, and the Senegal international's strike partner Demba Ba scored from the resulting penalty.
Ba then took his league tally to 10 this season, matching the leading totals of Michu, Robin van Persie and Luis Suarez, before Gael Bigirimana sealed the result in the second half to end a run of four defeats.

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