Lonnie Pryor, James Wilder Jr., and Debrale Smiley combined for seven rushing touchdowns Saturday to lead No. 7 Florida State to a 69-3 win over Murray State.
Pryor ran for three TDs, and Smiley and Wilder added two apiece. Wilder finished with 106 yards rushing.
Florida State (1-0) scored on their first touch of the new season on Rashad Greene's 47-yard punt return just 89 seconds into the game.
EJ Manuel passed for 188 yards and a touchdown before retiring midway in the third quarter.
Murray State's Casey Brockman passed for 117 yards, but was intercepted once and sacked six times, including four by Bjoern Werner.
The Seminoles totaled 606 yards while holding Murray State (0-1), a Football Championship Subdivision school, to 156 yards