He was sent off for his troubles but Ghana missed the penalty and Uruguay went on to finish fourth in the tournament.
The following year after his move to Liverpool, Suarez was found guilty of racially abusing Manchester United's Patrice Evra.
He was fined $63,000 and banned for eight matches.
Ahead of the World Cup, Suarez had undergone knee surgery, missing Uruguay's first World Cup game, before returning to face England, when he scored twice in the South American team's 2-1 win.
"Before the game people in England laughed about my attitude over the last few years," Suarez told reporters following the game.
"I want to see what they think now. I have dreamed of this moment."
Suarez enjoyed a sensational season with Liverpool -- scoring 31 league goals to help his club qualify for the Champions League.
He was voted Player of the Year by his fellow colleagues and also named as the journalists' Player of the Year too -- awards that reflected a feeling that Suarez had put behind him his troubled past.
But he now looks set to miss Liverpool's first nine Premier League games of the season and the start of the club's Champions League campaign.