Syracuse led 35-20 on the strength of Michael Carter-Williams' nine points and six assists.
The Cardinals closed to 17-15 before the Orange went on an 18-5 run to end the half. Carter-Williams fueled the run with all of his nine points.
Louisville went nearly five minutes before making its first basket, going 0 of 8 from the field and trailing 8-0.
Syracuse was in search of its sixth championship. It also won the tournament in 1981, 1988, 1992, 2005 and 2006.
Syracuse departs the conference as the most successful school in the storied history of the Big East. Its 366 regular-season wins are the most of any team in the league.
NOTES: Carter-Williams accumulated 36 assists in three Big East Tournament games. ... Pitino was an assistant coach for two seasons on Syracuse coach Jim Boeheim's first staff (1976-78). ... The Cardinals defeated the Orange 76-66 in the 2009 Big East tournament final. ... The Big East Tournament team consisted of Russ Smith (Louisville), Brandon Triche and James Southerland (Syracuse), Markel Starks (Georgetown) and Pat Connaughton (Notre Dame). ... Southerland set a tournament record for 3-pointers with 19.