Michael Penix Jr. won his debut as Atlanta’s starting quarterback, thanks largely to a defense that returned a pair of interceptions for touchdowns to hand the hapless New York Giants their franchise-record 10th straight loss, 34-7.

Marco Wilson and Isaiah Simmons scored touchdowns on two pick-6s late in the first half and used that stunning change in momentum to lift the Arizona Cardinals over the New Orleans Saints 42-34.

Kansas City Chiefs quarterback Patrick Mahomes (15) throws against the Denver Broncos in the second half of an NFL football game in Kansas City, Mo., Sunday, Dec. 6, 2020. (AP Photo/Charlie Riedel )KANSAS CITY, Mo. Hill never argued when it was called incomplete, nor did Chiefs coach Andy Reid throw the red challenge flag. Instead, he quickly sent his punt team out and tried to pin the Broncos deep in their own territory. Chiefs: CB Antonio Hamilton had to be helped off the field after blocking on a punt return early in the fourth quarter.

Start with running back, where Giants star Saquon Barkley is believed to have torn the ACL in his right knee early in their loss at Chicago. The 49ers' Jimmy Garoppolo tried to play through a right ankle injury before Nick Mullens took over for the second half. Tevin Coleman also left San Francisco's win over the Jets with a late knee injury. Along with Lock and Sutton, the Broncos lost defensive end Dre'Mont Jones to a knee injury in their defeat at Pittsburgh. Washington guard Brandon Scherff, who left early in Arizona with a knee injury, was among the offensive linemen hurt around the NFL on Sunday.