Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception 74 yards for a score to lead the San Francisco 49ers to a 48-27 victory at Indianapolis.

James Cook rushed for 117 yards and two touchdowns, leading the Buffalo Bills to a 23-20 victory over the Cleveland Browns.

Jason Myers kicked a franchise-record six field goals, including a 56-yarder with 29 seconds left, and the Seattle Seahawks outlasted 44-year-old quarterback Philip Rivers and the Indianapolis Colts 18-16.

Philip Rivers wanted one more shot at winning that elusive Super Bowl ring.

The Indianapolis Colts and Jacksonville Jaguars are 8-4 teams seemingly headed in opposite directions.

First place is on the line in three division matchups in Week 14.

The Houston Texans have narrowed the AFC South race with a 20-16 win over the slumping Indianapolis Colts.

The Kansas City Chiefs saved their season.

Jonathan Taylor completed a 244-yard rushing day with an 8-yard touchdown run in overtime to give the Indianapolis Colts a 31-25 victory over the Atlanta Falcons in the first regular-season NFL game in Berlin, Germany.

Josh Allen and the Buffalo Bills own Patrick Mahomes and the Kansas City Chiefs in the regular season.

Carson Wentz dislocated his left, non-throwing shoulder, tearing his labrum and fracturing the socket, in the first half of a game for the Vikings in London on Oct. 5 and kept playing, according to two people with knowledge of the injury.

The NFL can see another worst to first turnaround this season.

The Philadelphia Eagles had a few extra days off to seethe and regroup after a humiliating loss to the Giants.

A Lions-Chiefs matchup was considered a potential Super Bowl preview when the schedule came out.

Denver Broncos coach Sean Payton sounded content to let others debate Sunday’s leverage call against linebacker Dondrea Tillman.

Spencer Shrader made a 45-yard field goal with no time left after the Broncos were penalized for leverage on his missed 60-yard try, and the Indianapolis Colts beat Denver 29-28 for their first 2-0 start since 2009.

Saquon Barkley’s first season in Philadelphia featured record performances on the field, a Super Bowl title and a new contract that is the richest ever for a running back.

Playoff berths, draft positioning and more are up for grabs in Week 17.

Anthony Richardson ran for a 4-yard touchdown, his second of the game, with 46 seconds left in his return to the starting role to lift the Indianapolis Colts to a 28-27 victory over Aaron Rodgers and the New York Jets.

The Supreme Court has given homeowners another chance to force Bank of America and other large banks to pay interest on mortgage escrow accounts.

Rookie quarterback C.

When it comes to getting big games from playmakers, the New England Patriots and Green Bay Packers have been lacking at a historic level.

Gardner Minshew threw three touchdown passes and the Indianapolis Colts rushed for 170 yards, improving their playoff prospects with a 30-13 win over the sagging Pittsburgh Steelers.

Running back Jonathan Taylor will have thumb surgery on Wednesday and hopes to return to the Indianapolis Colts in about three weeks, a person with knowledge of the injury has told The Associated Press.

Jonathan Taylor ran for a first-quarter touchdown and Mac Jones threw a crucial interception in the fourth quarter and the Indianapolis Colts held on for a 10-6 win over New England Patriots in Germany.

Zack Moss upstaged the return of Jonathan Taylor by running for a career-high 165 yards and two scores and Gardner Minshew was sharp in relief of the injured Anthony Richardson to lead the Indianapolis Colts past the Tennessee Titans 23-16.

All-Pro running back Jonathan Taylor and the Indianapolis Colts have agreed on a contract extension.

A healthy Jonathan Taylor explained Thursday how happy he is to be practicing again with the Indianapolis Colts.

Coach Shane Steichen says the Colts will activate running back Jonathan Taylor from the physically unable to perform list and he could play Sunday against Tennessee.

Indianapolis Colts running back Jonathan Taylor will miss the first four games this season and general manager Chris Ballard isn't sure if or when the 2021 NFL rushing champ might return.

Miami's GM Chris Grier said conversations with the Indianapolis Colts about 2021 All-Pro running back Jonathan Taylor were “exploratory,” and no official offers were exchanged between the two teams.

A slew of trades highlighted roster cutdown day in the NFL.

The Indianapolis Colts are allowing disgruntled running back Jonathan Taylor to seek out a trade partner, a person with knowledge of the situation has told The Associated Press.

The Kansas City Chiefs are doing no favors to Jonathan Taylor, Saquon Barkley and every other running back that wants to get paid.

A person with knowledge of the situation told The Associated Press that Indianapolis Colts running back Jonathan Taylor has requested to be traded.

Can Jacksonville (2-3) get back on track after consecutive losses and win a pivotal AFC South game in Indianapolis (2-2-1) on Sunday?

A month after the Jaguars shut out the Colts in Jacksonville, the divisional foes meet in Indianapolis. Both teams will play without key starters due to injuries.

The Indianapolis Colts will face Jacksonville on Sunday without either of their top two running backs.

The issues that they needed to address were addressed. The Jaguars needed to fix quite a few things after their struggles to open the season and they did just that.

Trevor Lawrence threw two touchdown passes to Christian Kirk, and Jacksonville dominated short-handed Indianapolis 24-0 on Sunday for its eighth consecutive home victory in the series.

Tom Brady led Tampa Bay to a field goal on his first and only series of the preseason, but the Indianapolis Colts' backups rallied to beat the Buccaneers 27-10.

A deal for Drug Free Sport International to police medication in horse racing is in place two months before the Horseracing Integrity and Safety Authority takes effect.

A four-time MVP, three Super Bowl players and the beginning of a brother act.

Five players, including dynamic pass catchers Cooper Kupp and Davante Adams, are unanimous choices for The Associated Press 2021 NFL All-Pro Team.

The Indianapolis Colts badly botched a chance to secure an AFC wild-card spot by losing at Jacksonville 26-11 in the clown game.

Here are some athletes who were money in the bank for sports bettors this year: Indianapolis Colts running back Jonathan Taylor, Tampa Bay Buccaneers receiver Mike Evans and Los Angeles Angels star Shohei Ohtani.

Jonathan Taylor ran for 170 yards and scored on a 67-yarder with 2:01 left to help the Indianapolis Colts seal a 27-17 victory over the New England Patriots on Saturday night.

Leonard Fournette capped a four-touchdown game with a 28-yard scoring run with 20 seconds left to give Tampa Bay a 38-31 come-from-behind victory at Indianapolis.

The Jaguars followed up a win over the Buffalo Bills with a flat first half and another step back in a 23-17 loss to the Colts in Indianapolis.

Carson Wentz threw three touchdown passes and Jonathan Taylor rushed for 172 yards and two scores as Indianapolis beat the New York Jets 45-30.

The Los Angeles Rams are leading the Seattle Seahawks 23-13 early in the fourth quarter. The Los Angeles Rams have taken a 20-10 halftime lead over the Seahawks in their wild card game at Seattle. Metcalf to cut the Los Angles Rams' lead to 13-10 in the second quarter of their wild card game. The Buffalo Bills are taking a 17-10 lead over Indianapolis into the fourth quarter at Buffalo. Washington won the middling NFC East despite a 7-9 record to earn a home wild card game.

(Photo by Bobby Ellis/Getty Images)JACKSONVILLE, Fla. – The Jaguars’ 2020 season ended Sunday with a 28-14 loss to the Colts in Indianapolis. Instead of noting my four biggest takeaways from the game, I’m going to shift to my four biggest takeaways from the season. It’s time for operation tabula rasaAfter a season like the Jaguars have just completed, a hard reset is needed. But considering their role in the past season, and in truth, for the past three seasons, it’s time to wipe the slate clean and start over. At its best, an NFL team can bring a city together, increase commerce in the hometown, and give residents a rallying point.

(Photo by Justin Casterline/Getty Images)JACKSONVILLE, Fla. – The worst season in Jaguars history is over. The Jaguars wrapped up their 2020 season in familiar fashion on Sunday, with another loss, this one 28-14 to the Colts. It was the worst season in Jacksonville’s 26-year history, eclipsing a 2-14 effort under Mike Mularkey in 2012. It was the ninth loss of the season by 10 points or more, and the fourth straight game in which the Jaguars weren’t even competitive. But he couldn’t move the Jaguars with much consistency, was sacked six times and lost a fumble that set up a 1-yard Taylor touchdown run.

Pittsburgh Steelers wide receiver Diontae Johnson (18) makes a catch past Indianapolis Colts cornerback Rock Ya-Sin (26) for a touchdown during the second half of an NFL football game, Sunday, Dec. 27, 2020, in Pittsburgh. And even as the Steelers spent the first half against Indianapolis seemingly in a full-out sprint to get to the offseason as quickly as possible. It revived Pittsburgh's floundering season and delivered the Steelers the AFC North title. The defense kept Philip Rivers, rookie running back Jonathan Taylor and Indianapolis out of the end zone in the second half. “When we had everything to play for, we just didn’t have all the answers in the second half of a game we had to have.

Indianapolis Colts cornerback Isaiah Rodgers (34) jumps over Las Vegas Raiders fullback Alec Ingold (45) during the first half of an NFL football game, Sunday, Dec. 13, 2020, in Las Vegas. (AP Photo/Isaac Brekken)LAS VEGAS – Frank Reich found himself regularly amazed while he watched everything his Indianapolis Colts accomplished in their first trip to Sin City. He also marveled at the breakaway speed of Jonathan Taylor, who outran the Raiders' entire secondary on a 62-yard TD sprint. Moreau eluded two defenders on a 47-yard catch-and-run TD shortly before Agholor's 21-yard TD reception put the Raiders up 14-10 early in the second quarter. BIG CATCHMoore blew both teams' minds with his interception in the second quarter.

(AP Photo/AJ Mast)INDIANAPOLIS – Lamar Jackson fast-tracked the Baltimore Ravens' latest record-breaking achievement. He opened the second half with an up-tempo game plan that got Indianapolis' defense out of sync. After punting on their first five possessions and watching the defense score the Ravens' only points of the first half, Jackson switched it up. “I’m glad we did," Harbaugh said when asked about going fast in the second half. Linebackers Darius Leonard and Anthony Walker also were injured in the second half.

14 Badgers beat Illinois 45-7 on Friday night to open the pandemic-delayed Big Ten football season. Mertz became the first-team quarterback after returning starter Jack Coan underwent foot surgery on Oct. 7, leaving him out indefinitely. After Illinois fumbled the ball away on the game’s second play from scrimmage, Mertz hit fullback Jason Stokke for a 10-yard touchdown pass. Mertz responded to Illinois’ touchdown by throwing a 34-yard completion to Ferguson and then hitting the senior tight end again for a 14-yard score with 1:06 left in the half. After Illinois went three-and-out on its next series, Mertz threw deep and found Danny Davis for a 53-yard touchdown pass with 28 seconds left until halftime.