The Soca Warriors have already qualified and will win the group with a draw, while Guatemala still have an outside chance at qualification.
They host winless St. Vincent and the Grenadines and are expected to cruise to three easy points.
Per U.S. Soccer, Trinidad and Tobago have never beaten the Stars and Stripes on American soil.
For manager Jurgen Klinsmann and his troops, Tuesday's task will be a simple one: Don't lose to the Soca Warriors, and the Stars and Stripes' 2018 World Cup hopes remain alive.
St. Vincent and the Grenadines have yet to earn a point in the fourth round, and the side barely put up a fight in their last outing at home against the USA.